禮來制藥創新研究獎項目

禮來制藥創新研究獎(LIFA)項目啟動于2012年,創立的宗旨是識別并培養尋求突破性研究項目的杰出博士后科學工作者。這一項目非常權威,采用了博士后科學工作者與自己的學術導師和禮來制藥科學家(擔任行業導師)結成對子的形式,以推進研究人員提出的創新研究提案。LIFA項目的目的是專注于將在對禮來制藥有重大戰略利益的科學領域推動創新的研究主題或“巨大挑戰”,同時足以培育顛覆性創新。禮來制藥選定博士后科學工作者后,他們將同時在學術機構和禮來制藥的研究中心工作,可接觸禮來制藥的科學家和相關技術,以推進其研究計劃。

相關研究項目可促進職業發展,且在性質上是非競爭性的;因此,禮來制藥鼓勵且期待此類結果的發布。除了參與項目本身外,該項目還提供職業發展資源及其他收益,包括長達四年的薪資、福利和參加科學會議的規定差旅補助。

參與本項目的資格目前僅限定于世界各地的受邀學術研究中心。

詳情請點擊下面的其中一個方框,或發送電郵至LIFA@Lilly.com

項目申請資格

LIFA項目僅邀請全球已選定的學術研究中心參加。應由各自所在機構的院長辦公室向禮來制藥提交申請。有意向的申請人可聯系其院長,了解更多信息。

要想符合申請該項目的條件,申請人須:

  • 持有2014年8月1日之前授予的博士學位(哲學博士、醫學博士或同等學位),且在2014年8月1日最多6年前獲得學位
  • 獲得學術導師將擔任其博士后擔保人并在申請流程中為其提供支持的承諾
  • 博士后職位不得以能否獲得LIFA資金支持為前提

項目收益

禮來制藥認識到,許多博士后培訓項目并不總能幫助年輕科學工作者做好擔任向他們提供的各種工作機會(學術、行業、生物工程/創業、政府、非盈利研究)的準備,因此設計了這一項目,以拓寬博士后科學工作者的培訓經驗。

這一項目成功的關鍵,是確立真正意義上的學術-產業培訓合作關系,由博士后科學工作者及其學術導師與擔任行業導師的禮來制藥的專家結成對子。博士后科學工作者一般將同時在學術機構和禮來制藥研究中心工作,可接觸禮來制藥的科學家和相關技術,以推進研究人員提議的創新研究項目。這些研究項目的設計性質是“非競爭性的”,以鼓勵結果數據的發布和展示。

項目收益包括:

  • 長達四年的全部博士后薪資和福利
  • 參加科學會議的規定博士后差旅補助
  • 每年向大學支付款項,以支持博士后科學工作者的培養
  • 從大學到禮來制藥研究中心工作的搬遷支持
  • 參與禮來制藥博士后科學工作者發展項目
  • 與禮來制藥全球科學網絡交流,并成為禮來制藥當前博士后科學工作者和校友社區的一份子

巨大挑戰

禮來制藥很自豪地介紹2014年前五項巨大挑戰。這些巨大挑戰及一些相關“尚未解決的關鍵問題”均經過精心設計,旨在確保禮來制藥總體科學戰略與LIFA項目未來的博士后研究項目的一致性。這些尚未解決的關鍵問題不應被視為優先研究主題,而應作為與禮來制藥巨大挑戰有關的研究領域的具體示例。

  • 在藥品發明和研發流程中及早確認臨床療效和安全性
    • 我們如何迅速確認人類疾病靶點及相關風險?
    • 是否存在能可靠且可預見地轉移至人類的動物疼痛或認知模型?
    • 自適應基于判斷的體系能否運用于既定靶點或臨床研究的數據評估?
  • 要想發現能為相應患者識別正確藥品的機制
    • 為什么抗抑郁藥對30%患有重度抑郁癥的患者無效?能否輕松識別這些患者?
    • 哪些技術(如診斷學、成像、分析化學、“大數據”分析)最能為特定疾病狀況的治療選擇提供有用信息?
    • 在關節炎的疼痛癥狀中,軟骨下骨質量起什么作用?
    • 在受傷和老齡化過程中,突觸后信號傳送在功能性神經-肌肉接頭重組中發揮什么作用?
    • 巨噬細胞計劃在肌肉修復和再生中是否發揮作用?
  • 提供出色的患者恢復結果
    • 如何檢測微轉移癌癥?
    • 我們如何迅速確定是藥品治療、合并用藥還是終止用藥取得了理想的結果?
    • 對于目前服用標準治療藥物的危險患者,導致心臟病發作的、未得到治療的因素或途徑有哪些?
  • 簡化大規模生化蛋白質生產,盡可能減輕環境影響
    • 為實現“綠色”合成流程,如何應用靈活的制造策略?
    • 哪些蛋白表達方法尚不成熟?大規模生物分子生產尚存在哪些障礙?
    • 可采用哪些策略來提高按比例縮減模型及預測工具的可靠性,以減少開發治療性蛋白制造流程的成本和時間?
    • 如何為蛋白生產開發更穩健的替代性(非哺乳動物)表達系統?
  • 精準安全地定位并提供生物制劑和小分子療法
    • 哪些策略有助于確保大生物分子在口服上具有生物藥效應以及/或大腦穿透性?
    • 先進的分析學和信息學能否提供相關方法,確保同時優化不同參數的分子?
    • 能有效提供具備非理想物理化學特性的強效口服藥的新一代配方方法有哪些?
    • 我們能否利用謹遵醫囑的給藥方式,例如抗體-藥物偶聯物(ADC)?

目前參與 LIFA項目的禮來制藥治療和職能領域包括:

  • ADME/藥物處置
  • 分析科學
  • 自身免疫和炎癥性疾病
  • 生物分子科學與工程
  • 心血管病
  • 化學工程
  • 糖尿病
  • 診斷學
  • 給藥和裝置
  • 健康結果研究
  • 信息學
  • 醫學/發明化學
  • 肌與骨骼疾病
  • 神經系統科學(疼痛、神經退化、精神病)
  • 腫瘤學
  • 制藥科學(生物制劑和小分子)
  • 工藝化學
  • 蛋白生產
  • 監管科學
  • 統計學
  • 定制療法
  • 毒理學
  • 泌尿學
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