結核病藥物發明工作

improving global health

作為禮來制藥耐多藥結核病全球合作項目的一部分,我們致力于為新型結核病藥物的研究提供支持。目前用于治療結核病的大多數藥物均有至少50年的高齡,需要花費很長時間才能起效,且副作用不斷減弱。

禮來結核病藥物發明計劃

禮來制藥于2007年推出了禮來結核病藥物發明計劃,它是一項非營利公私合作項目,宗旨是加速早期的藥物發明。這項計劃的總部位于華盛頓州西雅圖,匯聚了來自各國政府、慈善機構、制藥企業、大學和其他研究機構的代表,以尋求全新結核病治療方法。

禮來結核病藥物發明計劃最重要的目標,是為渠道補充新的結核病藥物。該計劃的創始成員,代表著獨特的、由財團維系的私營部門、非營利組織和公共部門,包括禮來制藥、傳染病研究所(IDRI)以及美國國立衛生研究院國家過敏癥和傳染病研究所((NIAID)。2009年,臺灣科學院也作為貢獻成員加入了這項計劃。

傳染病研究所(IDRI)

我們與位于西雅圖的傳染病研究所密切合作,為其尋找新型結核病藥物的研究工作提供支持。從2008年到2016年,我們已向傳染病研究所提供超過2000萬美元的資金支持和實物捐贈。在最初階段,我們提供了啟動資金支持,幫助傳染病研究所設立了設施完善、處理能力較強的篩選和化學實驗室。

我們還開放了禮來制藥的研究工具及目前含有800,000多個分子實體的公司化合物庫。傳染病研究所可使用創新性篩選方法,借助潛能高、結構新穎的防結核病化合物,并利用這一化合物庫來填補整個研究渠道。此外,禮來制藥的科學家們還可以自愿抽出時間,協助傳染病研究所開展發明工作,貢獻自己的科研和技術專長,以及探尋新型結核病藥物的熱情。

結核病藥物加速器項目

禮來制藥是結核病藥物加速器項目(TBDA)的成員之一,TBDA是由8家制藥公司和7家研究機構推出的一項開創性項目。這一合作項目的目標通過在早期研究中合作,發明新型結核病藥物。長期目標是創建能夠在短短一個月內治愈患者的結核病給藥方案。

之所以說這一合作項目比較獨特,是因為它擺脫了傳統的研發慣例。各成員攜手合作,無論藥物起源于何地,均可制定最佳預期。通過該項目確定的先導化合物的結構將最終放回公共領域。在獲得比爾和梅琳達·蓋茨基金會近2000萬美元的資金支持后,TBDA于2012年正式啟動。目前已完成首輪新型結核病藥物的篩選,化合物進展迅速。

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