回饋中國全球醫療保健創新計劃

耐多藥結核病全球合作項目在中國

結核病被列為中國重大傳染病之一,是嚴重危害中國人民健康的呼吸道傳染病。目前中國每年報告新發肺結核患者約100萬人,是世界第二大結核病高負擔國家。耐多藥結核病(MDR-TB)是結核病的一種,死亡率高,對健康人群威脅極大,且治療周期漫長,治療費用較高,由于其迅速傳播擴散,有可能導致結核病再次成為“不治之癥”。中國每年新發的耐多藥結核病病例占全球總量的1/4,而其中大概只有3%的病例被診斷和報告,僅2%的患者得到了規范治療。

為阻止耐多藥結核病在全球的蔓延,挽救人們的生命,禮來制藥于2003年6月開始,啟動了公司歷史上規模最大的公益項目— — “禮來耐多藥結核病全球合作項目”(Lilly MDR-TB Partnership),并于同年正式進入中國。在中國,禮來致力于與各級、各類合作伙伴一道,積極致力于尋找預防、治療和監督這種疾病的最佳解決方案。通過技術轉讓、健康促進和專業培訓等主要領域全面出擊,在耐多藥結核病的政策倡導、國內外學術交流、社區公眾和易感人群教育培訓、少數民族地區結核病知識普及教育等方面做出了不懈的努力并付出了相當的資金投入。

從2003年到2016年,禮來以現金、藥品、技術轉讓、培訓及結核病藥物研發投入等方式,總投入達到1.7億美元用于對抗耐多藥結核病的全球威脅。

技術轉讓

  • 禮來分別向全球七家公司轉讓了卷曲霉素、環絲氨酸的生產技術,加強耐多藥結核病藥品的供應和可及性。中國、印度、俄羅斯和南非等四個疾病高發國家的公司獲得了禮來的技術、知識和商標以及培訓和財務支持。
  • 2005年8月,禮來公司將卷曲霉素從原料到制劑的全套生產技術無償轉讓給了中國浙江海正藥業,并提供資金用于培訓,以提升海正藥業在管理、人員等方面的水準,確保其生產出具有國際一流品質而價格相對低廉的藥品。使得海正藥業成為全球第二家利用禮來公司專利技術生產高品質卷曲霉素的公司,并成為禮來全球耐多藥結核病合作項目中唯一的中國制藥企業。
  • 2011年10月24日,浙江海正藥業以禮來專利技術生產的卷曲霉素新劑型(凍干粉針)取得國家食品藥品監督管理局注冊批件,并于2012年1月起正式供應中國市場。
  • 2015年3月,禮來在中國正式發布了耐多藥結核病技術轉讓白皮書。詳細梳理了禮來做出技術轉讓決定的初衷、過程和心得體會。對結核病高負擔國家二線抗結核藥物的市場需求、生產供應、注冊準入及轉讓技術壁壘等問題進行了深入的探討。希望藉此為全球特別是結核病高負擔國家的藥品生產企業、注冊監管部門和國家結核病防控機構提供借鑒。禮來認為,成功遏制耐多藥結核病的蔓延,取決于各國政府、NGO和企業界的共同努力和全社會的共同關注。

禮來MDR-TB項目第三階段在中國

2012年3月20日,中國疾病預防控制中心與美國禮來基金會在京簽署了關于耐多藥結核病戰略合作項目的諒解備忘錄。這標志著“禮來耐多藥結核病全球合作項目”第三階段正式在中國啟動。全國人大常委會副委員長、時任衛生部部長陳竺先生出席簽字儀式并做出重要指示,勉勵禮來 “將政府意志、人民期望和企業社會責任有機地結合起來,為推動我國的MDR-TB防治、管理工作貢獻力量。”

項目第三階段在中國開展工作的主要合作方包括中國疾病預防控制中心,中華醫學會結核病學分會,青海省疾病預防控制中心、世界衛生組織(WHO)、紅十字會與紅新月會國際聯合會(IFRC)、 國際護士會(ICN)和中華護理協會(CNA)等國內外合作伙伴。在國家衛計委的統一協調下,結合中國結核病防控規劃和區域發展重點,形成了以西部為重點,東、中、西結合的項目布局,國家CDC和結核病學分會的培訓項目將各自建立6個省級培訓中心并向周邊輻射,分別針對疾病系統和定點專科醫院,按照“研究-報告-倡導”的指導思想,致力于中國耐多藥結核病相關醫護人員的培訓和能力建設,探索開發具有中國特色的耐多藥結核病培訓模式并使之得以推廣,從而全面提高中國耐多藥結核病的防控水平。加之與青海省疾控中心的合作和其它國際合作伙伴在中國開展的項目,整個第三階段的固定項目落戶在全國12個省市自治區),并通過示范中心輻射全國。

項目第三階段,禮來基金會通過“全球聯合之路”(United Way Worldwide)對中國的項目合作伙伴及在華開展工作的國際合作伙伴的總投入超過 500萬美元

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