關鍵問題上的立場

禮來致力于生產能夠滿足患者醫療保健需求的藥品。我們相信,我們的產品能夠拯救和改善生命,因此應確保患者能夠獲得我們的產品。正因如此,作為負責任的企業公民,禮來積極參與政治進程,向全球公眾公布與醫療衛生有關的討論結果以及藥品研究創新結果。 為確定哪些問題是需要參與的最相關的問題,禮來會考慮多種因素以及利益相關方的意見。這些因素包括患者需求、與利益相關方的談話和訪談、投資者問題和反饋、業務戰略、公共政策對話和立法辯論,以及員工利益。

知識產權保護

未來的生物制藥創新取決于知識產權的保護,禮來提倡對知識產權進行健全有效的保護,以確保投資者享有在限定期限內獨家開發和銷售新藥的權利。

藥品的可獲得性和可承受性

鑒于藥品的可獲得性可能受到諸多經濟、政府和社會因素的影響,因此禮來制藥專注于能夠以己之力對其產生影響的領域。我們攜手合作,制定相關解決方案,幫助發展中國家的患者獲取藥品。

基于價值的定價

禮來制藥相信,我們的藥品價格能夠體現各自的價值。 在為藥品定價的過程中,我們會考慮向患者、提供商、支付者和行業提供的價值。

比較效果研究

禮來制藥支持開展比較效果研究,以幫助醫師和患者做出相關治療決定、探討全面改善醫療衛生體系的機會,并解決公共衛生挑戰。

聯邦醫療保險計劃處方藥費

美國聯邦醫療保險計劃中的處方藥津貼是一個范例,即競爭性私營市場是能否為患者提供最佳護理的關鍵。禮來制藥認為,必須維持處方藥費的競爭性價值。

醫療改革

禮來制藥認為,有效的醫療衛生政策取決于藥品獲取、品質和成本的均衡性。我們支持相關醫療改革計劃,將醫療衛生的獲取延伸至目前缺乏藥品的患者,同時對于那些目前可以使用藥品的患者來說,保護或改進他們的藥品獲取情況。

個性化醫療

個性化醫療(又稱“量身定制的治療”)有望為個別患者提供更高的精確性、更高的價值以及經過改善的治療結果。這是禮來生物制藥創新愿景的核心。定制正被融入每一單獨的藥品研發項目,同時使用多種方法識別不同患者群體之間的差異性。這包括:

  • 表型特征(如年齡或體重)
  • 已建立的生物標記(如HbA1C水平)
  • 源自新工具和技術的更多新穎標記(如藥物基因組學、生物影像和生物信息學)

所有這些方法正在推進我們對患者的理解、分類和處理方式。除了根據個性化護理開展的新藥和方法創新外,禮來正努力進一步革新我們的商業模式,確保新藥研發和影響更有成效、更高效,滿足患者的需求。

為滿足患者、提供商和支付者的需求,禮來量身定制的治療策略必須依托于能夠認同和獎勵創新的政策環境。能夠為藥物的個性化方法提供支持的、最重要的政策主題包括衛生技術評估、基于價值的定價和基于科學的監管體制。

知識產權

禮來提倡對知識產權進行健全有效的保護,包括對醫藥產品的專利保護。生物制藥行業取決于知識產權的保護情況,因為知識產權保護可授予新藥發明者在限定期限內獨家開發并銷售新藥的權利。

沒有知識產權保護,藥品研發公司將無法收回每研發一種新藥所需要的約8 - 13億美元的平均投資。缺乏有效的知識產權保護,將抑制制藥業研發新藥、挽救全球患者的能力。

禮來認識到國際社會在改進和協調知識產權保護方面的重要作用。我們將進一步支持制定國際貿易協定,推動在此前知識產權保護力度不足的重要市場推行更有效的專利保護。

禮來還意識到美國相關貿易法律與世界貿易組織(WTO)的相關條款在知識產權保護領域作出的重要貢獻。我們將繼續支持這些法規的實施,以鼓勵發展中國家提供有效的藥品專利保護措施。遵守WTO知識產品保護規定,有助于(吸引更多投資,保留本地人才,從而)推動經濟增長,確保提供更多的創新藥品。但是,禮來不尋求在最不發達國家(參見WTO的定義)中獲得相關專利。

倫理上的互動

通過促進新藥的研發,提高個體和公眾健康水平,醫師或醫學研究人員與生物制藥企業之間的合作可以惠及社會。但是也存在令人擔憂的問題,即由于存在可能對專業判斷產生不當影響、從而損害科學實驗的誠信以及患者護理的質量的風險,這些關系可能產生利益沖突。

禮來僅為合法合理且必要的服務向衛生保健提供商支付相關款項,金額不超過所提供服務的公允市場價值

  • 對于開展禮來贊助或支持的醫學研究的衛生保健提供商,禮來將因其執行研究程序并收集相關數據適當支付酬勞。
  • 甄選服務提供商時,禮來將選擇有資格且適合執行此類服務的提供商。禮來不會優先選擇本身是禮來客戶的服務提供商,且不會以購買禮來產品作為甄選服務提供商的條件。
  • 禮來不會出于獎勵過往或更改當前/將來處方慣例的目的向衛生保健提供商支付任何款項。
  • 禮來不會出于產品體驗或了解產品信息的目的向衛生保健提供商支付任何款項。 禮來認為,限制創新型企業直接與醫學專業人士打交道的相關政策,會妨礙醫學知識和患者護理的進步。

行業透明性

根據公司此前積累的經驗,業務經營的透明性有助于構建與利益相關方的信任關系。透明性還有助于防止腐敗和不道德的業務實踐。仔細聆聽利益相關方的顧慮,并做出公開回應,可以改善透明性以及公司的業務經營方式。

禮來認為,對于牽涉向醫師支付財務款項或其他非現金價值形式的業務實踐而言,必須保持透明性,這對構建與公眾的信任關系而言至關重要。禮來還認為,應就醫療衛生專業人士在藥物研發過程和醫學教育中提供的服務提供公平報酬。但是,我們也認識到,如果對此諱莫如深,那么這些關系也可能會被誤解。因此,我們已采取諸多措施,提供關于我們與主要合作伙伴互動方式的重要方面的信息,尋求實現醫學進步。

2004年,禮來成為首批自愿向公眾披露美國臨床試驗結果(即使是不利的結果)的公司之一。2007年,禮來成為第一家公開報告向美國境內機構提供的資金支持的制藥企業,其形式為 教育基金和慈善捐贈 ,旨在為我們認為能增加醫療衛生知識并改善患者護理的醫學教育、患者教育和其他重要活動提供支持。自2008年至今,禮來一直在披露向歐洲患者組織提供的財務支持。

2009年,禮來推出了“特許注冊”,這是一個向美國外部醫療衛生專業人士支付的相關款項的列表。此類人士往往通過簽署協議,基于他們的經驗和專業技術執行教育項目,并為我們提供咨詢服務。2011年,我們開始披露向 禮來醫師款項注冊 中美國境內所有醫師支付的研究和其他款項,以及非現金形式的價值(如商務餐和商務差旅費用)。

基于價值的定價

禮來認為,我們的藥品價格能夠體現它們為患者、提供商、支付者和整個社會帶來的價值。在制定價格時,我們會根據現有數據,納入我們對價值的理解。

為衡量新藥的價值,一般要進行評估,主要是利用衛生技術評估(HTA)。公眾支付者日益尋求利用此類評估結果來開展定價談判。禮來認為,正如醫學實踐不能也不應采取一刀切的方法來治療和治愈病患一樣,用于實現基于價值的定價的方法也應該是靈活的,應該認識到價值的復雜性、臨床研發的復雜性、醫學實踐的復雜性,以及能激勵為將來的制藥研發提供資金支持的創新的復雜性。

HTA為價值判斷和定價決策提供相應信息的能力,部分取決于獲得監管批準之時所提供的、關于新藥比較效果和安全性的全部證據。要生成全部價值證據,可能需要超出批準時間安排的范疇。鑒于此,定價和補償體制可能需要具有靈活性,并為“擴大證據獲得同時支付的政策”提供相關選項。初始價格和獲取水平需要根據這些選項確定,并遵循將來可能提供的更全面的證據。

對于基于價值的任何定價方法,應以全面的方式考慮價值,包括患者、提供商、支付者和行業的觀點。對于藥品價值的判斷,不應僅僅體現于其最終價值本身。通過就患者及時獲取新藥的補償和程度做出決定,還存在價值認可和獎勵的機會。

HTA新藥評估的結果,可以為基于價值的定價談判提供信息。但是,如果希望通過HTA提供定價信息,HTA流程就必須考慮新藥可為患者和其他利益相關方(包括能為社會帶來的效益)帶來的全部價值。更多信息,請參見禮來有關衛生技術評估的政策立場。

除了在醫療衛生決策過程中可以考慮價值的定價外,還可以采取其他方法。禮來提倡探討不同的創新性支付模式,此類模式要求利益相關方廣泛參與藥品研發和實施流程、影響的評估以及相關措施的制定,目的是為改善患者治療結果和護理整合提供支持。有助于改善患者治療結果和醫療體制相關流程的支付方法和項目(如基于價值的收益設計)可能會更有前途,而不是所提供服務的數量。所希望的結果可能是但不限于死亡率的降低和壽命的延長、遵循相應的臨床最佳實踐標準,以及護理水平的提高,例如減少住院治療的天數或提高生活質量。

可獲得性與可承受性

全球有數百萬人缺乏藥品和其他形式的衛生保健的獲取渠道。藥品獲取是一個復雜的全球性問題,根據地理位置的不同,可能會有不同的表現。不同的經濟發展水平、政府所扮演的角色以及提供衛生保健的方法,均會影響藥品的可獲得性和可承受性。改善藥品的獲取是一項巨大挑戰。要解決這一問題,就需要各國政府、私營部門、多邊機構和民間社會共同做出最大努力。

禮來制藥意識到,我們無法解決所有的問題, 因此我們專注于能夠以一己之力對其產生影響的領域。禮來制藥將堅持不懈地致力于研發新藥以滿足重要健康需求的企業使命。沒有創新性藥品,身體的健康將成為空談。

禮來制藥意識到,我們的藥品價格不僅僅應反映它們提供的價值,保障今后的藥品研發,還應考慮到藥品的可獲得性。在全球范圍內,禮來制藥與發展中國家以及欠發達國家的政府合作,探尋改善藥品可獲得性的合理措施。這些措施包括為患者援助項目捐款捐物、國際人道主義援助、其他類似的慈善措施以及公私合作伙伴項目。與此同時,禮來制藥還采取相關的商業措施,一方面對患者護理產生可估量的積極影響,另一方面從長遠的角度關注并解決發展中國家基礎設施不完備的問題。

禮來制藥相信,允許藥品差別計價的醫療體制能夠在獎勵創新與保障低收入人群獲取藥品這兩方面取得平衡。這一特性能夠同時保證藥品的可獲得性與進一步的研發,有利于患者、公私醫療管理機構以及相關產業。但是,要想確保差別定價的有效性,其背后必須有良好的政策環境的支持。在該環境中,對于參考價格的定價是自由的,并且低價折扣的藥品不被允許流入擁有更高收入的市場。

醫療改革

禮來制藥提倡所有美國人均獲取價格適中的私營醫療保險服務。美國人口超過3億,呈現多樣化特征,且都有自己的獨特需求,因此美國的醫療改革沒有統一的解決方案。

禮來制藥認為,有效的醫療衛生政策取決于藥品獲取、品質和成本的均衡性。我們支持相關醫療改革計劃,將醫療衛生的獲取延伸至目前缺乏藥品的患者,同時對于那些目前可以使用藥品的患者來說,保護或改進他們的藥品獲取情況。這包括擴展覆蓋范圍,讓個體注冊自己符合資格的公開項目。

與政府管理的制度相比,禮來制藥更喜歡自由市場的解決方案。以下舉措有助于鼓勵參與醫療體制:無論美國人是單獨還是通過自己的雇主購買醫療保險,均給予美國人相同的稅務優惠;實施醫療責任保險改革;以及擴展健康儲蓄賬戶(HSA)和以消費者為導向的其他醫療保險模式。

禮來提倡以患者為中心的實踐,此類實踐能幫助個體及他們的醫師和醫療衛生提供商做出有關自身衛生保健的明智選擇。健康保險利益的設計,應促進醫患關系,并認識到處方藥品和其他創新成果在提供低成本衛生保健中所發揮的不可或缺的作用。

禮來制藥不提倡單一給付的體制。這些政府體制為在其他國家工作提供了諸多可能性,且相關證據也顯示,它們極不理想。單一給付體制抑制了創新,因而也就限制了藥品獲取、配額護理,消除了競爭,且妨礙了質量的提高。

政府所扮演的角色,應主要是為醫療基礎設施提供的其中一種財務和行政支持,例如補貼和促進設立適用于以下各項的標準:迅速部署醫療信息技術、設立質量標準并促進安全保障。

禮來制藥制定了醫療改革四大原則,具體包括:

  • 禮來制藥支持能夠保護和鼓勵患者在管理自身及家庭健康的過程中做出選擇的相關改革。
  • 禮來制藥支持可確保患者成為自身健康負責任的參與者,同時要求醫療領域的所有參與者對患者負責的醫療改革。醫療領域的所有參與者包括保險公司、醫療衛生提供商、支付者、監管機構和創新型企業。
  • 禮來制藥支持能夠保護和促進自由市場競爭的醫療改革,其方式為根據向患者提供的質量和價值,獎勵醫療衛生提供商和創新型企業。
  • 禮來制藥支持能夠提高衛生保健交付質量和效率的美國醫療改革,從而減少浪費,降低系統成本。

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