歷史傳承

公司歷史

禮來制藥(Eli Lilly and Company)擁有140多年歷史,是一家以研究為基礎的全球性企業,于1876年5月創建于美國中西部印第安納州的印第安納波利斯市,創始人為禮來上校。作為一名38歲的藥劑師和美國內戰的退伍軍人,禮來上校對當時那些配方粗糙、藥效較差的藥物非常失望。

  • 他要成立一家生產最高品質產品的醫藥公司。
  • 他的公司將僅僅生產需要醫生處方的藥品,而絕不是江湖術士花言巧語盲目推銷的偽劣產品。
  • 禮來的藥品將采用最先進的科學技術開發和生產。

盡管他的業務發展得一帆風順,禮來上校還是對傳統的藥品監測方法感到不滿。1886年,他雇傭了一位年輕化學家擔任全職的研究員,通過運用及發展最新的科學技術進行質量檢驗。他們一起為禮來的傳統奠定了基礎,那就是:首先致力于提高現有產品的品質,繼而發展到發明和開發新的更好的藥品。

后來,禮來上校的兒子Josiah K. Lilly Sr.和兩個孫子(Eli Lilly和Josiah K. Lilly Jr.)先后擔任公司的總裁。均為公司的管理作出了獨特的貢獻。這些管理風格逐漸形成了公司的文化,在這一文化中,員工被視為最有價值的財富,至今這仍是公司經營哲學的核心。一個多世紀以來,禮來員工一直在努力發明和研發眾多突破性的產品。

醫療領域突破性貢獻

1880年代

禮來是最早啟動真正研發項目的制藥公司之一,并雇傭了一名藥劑師作為公司的第一位研究人員。

1920年代

我們的研究人員與多倫多大學的弗雷德里克?班廷(Frederick Banting)和查爾斯?貝斯特(Charles Best )合作,提取并純化用于糖尿病治療的胰島素。糖尿病當時是一種致命性疾病,缺乏有效的治療方法。1923年,禮來推出世界上第一種動物胰島素產品因蘇林并進行大規模生產。

禮來啟動了關于一種可威脅生命的血液病——惡性貧血的療法研究項目,并推出了一種動物肝浸膏產品,確立了過去幾十年來的治療標準。作為公司在這一項目中的合作者,來自哈佛大學的兩名研究人員隨后因發現貧血癥的肝臟療法而分享諾貝爾獎。

1940年代

最早研發世界上第一種抗生素——青霉素大規模生產方法的公司之一,標志著抗擊感染病的持續努力的開始。

1950年代

強效抗生素萬古霉素誕生,至今仍是某些類型的耐藥菌引發的嚴重院內感染患者的最后一道防線。

推出廣譜抗生素紅霉素,為青霉素過敏患者帶來了更多選擇。

1960年代

推出新一類口服和注射用抗生素頭孢菌素。此后20年內,禮來取得重大突破,實現了此類產品的大規模生產,包括Keflex? 和Kefzol?

禮來還推出了長春新堿和長春堿,它們是名為長春花生物堿的抗癌藥物,源自玫瑰紅色的長春花屬植物。

1970年代

推出頭孢菌素家族的成員希刻勞,隨后即成為世界上最暢銷的口服抗生素。還推出用于治療心血管疾病的創新藥物Dobutrex?

1980年代

禮來1982年推出世界上第一個人工基因合成的人胰島素優泌林,是全球首個應用重組DNA技術創造的人用醫療產品,也是20世紀20年代以來糖尿病領域取得的最重大的突破。隨后將這一技術應用于兒童生長激素缺乏癥的新療法——重組人生成激素。

禮來推出新一類抑郁癥治療藥物的首個主要產品百優解。

1990年代

禮來推出一系列創新產品,包括治療胰腺癌和非小細胞肺癌的藥物健擇?;心血管藥物ReoPro?,可預防某些心臟手術(如血管成形術)后血栓的形成;至今仍為全球最暢銷的精神分裂癥藥物再普樂?;能夠快速起效的賴脯胰島素注射劑優泌樂?,給藥更便利,可改善血糖控制;以及用于預防和治療絕經后婦女骨質疏松的新一類藥物中的首款產品 - 易維特?。1999年,與日本武田制藥公司合作,成功推出口服降糖藥Actos?

2000年,禮來推出又一種用于治療死亡風險高的成人重膿毒癥的創新性藥物Xigris?

2002年,用于治療男性勃起功能障礙的藥物希愛力獲準在歐盟上市;隨后于2004年在美國推出。用于治療骨質疏松癥、促進新骨再生的創新性藥物復泰奧?也獲得批準。用于治療注意缺陷及多動障礙的非興奮性、非控制性藥物擇思達?也獲得批準。

2004年,在美國推出第一種也是唯一一種獲得美國食品和藥物管理局(FDA)批準的藥物Symbyax?,用于治療雙相情感障礙抑郁發作。力比泰?獲得批準,可與標準化療藥物順鉑結合使用,治療惡性胸膜間皮瘤。欣百達?也獲得批準,成為治療抑郁障礙及糖尿病周圍神經痛的一種新藥物。

2005年,作為用于治療2型糖尿病、名為腸促胰素類似物的新一類藥物中的首個產品,百泌達?在美國獲得批準并上市。

2006年,健擇獲準用于治療復發性卵巢癌,這標志著這一抗癌藥物第四次獲得美國食品和藥物管理局(FDA)的批準。

2007年,美國食品和藥物管理局(FDA)批準治療骨質疏松癥的藥物易維特? ,以降低兩種絕經后女性群體罹患浸潤性乳腺癌的風險,即患有骨質疏松癥的的女性以及浸潤性乳腺癌的高風險女性。FDA還批準了欣百達,用于成人重度抑郁障礙(MDD)的維持治療。

2008年,希愛力?一日一次劑型獲得FDA批準,可用于治療男性勃起功能障礙。

2009年,Effient?獲得FDA批準,可用于接受名為皮冠狀動脈介入治療(PCI)的動脈開張術的急性冠狀動脈綜合征(ACS)患者的治療,以減少血栓形成的相關心血管事件的發生率。PCI 通常要為患者植入支架,幫助患者開通動脈。

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